| Term | Definition |
| Sanguinary | Eager for blood or bloodshed. |
| Sanguineas | Bloody or covered in blood. |
| Sanguis effundatur | Let blood be poured out. |
| Sanguis Fluat | Let the blood flow. |
| Sangunet | Let him/her/it bleed. |
| Shapeshifter | Supernatural being that can change into an animal. True shapeshifters, which are rare, can change into any animal they saw last, wherever it be alive, dead, pictures or movie, etc. |
| Slave | A human that is kept as a pet for "little drinks" or light feeding. |
| Silus | A very evolved vampire, belonging to "The Brotherhood" in a futuristic world. A sweet, sensitive and "perfect creature." |
| Silver | A metal used to hurt and control vampires. It can cause severe injury and though it doesn't result in death unless in bullet form, it can eventually lead to the vampire's death owing to weakness. In folklore, all of the Undead can be killed with silver. The reason vampires had no reflection and could not be photographed was because of silver -- old mirrors were backed with silver and film developing used silver nitrate. Because silver is no longer used for mirrors, and there is none in digital photography, modern vampires would cast a reflection and show up in digital photos. |
| Sino-AIDS | An AIDS-like disease carried by humans, which can infect vampires who ingest the infected human's blood. Usually, it makes the vampire incredibly weak and eventually can result in final death. |
| Sire | What a vampire calls the vampire that brought him or her over. |
| Sheriff | The term given to a vampire who has been entrusted an area of a state by their King or Queen. They are given the responsibility to monitor vampire activity within their area, earn money through tourism and businesses, and insure that their own vampire laws are followed. |
| Stake | Historical weapon of choice against vampires; it is a simple wooden pole with a sharpened end. When thrust through a vampire's heart, it causes instant and final death in "True Blood." In folklore, the vampire may be able to pull the stake out unless the head is removed, mouth stuffed with garlic and turned face down. |
| Supe | Slang or shortened term for a supernatural being. |
| "Take the Night from the Dead" | Anti-vampire movement.
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| The Old World | A reference to the areas now known as England/Europe. |
| The Two-Natured | Slang for Shapeshifters, referring to their human and animal form. |
| Tourist | (As it relates to vampire bars) they visit vampire bars and just wear anything black that they already had in their closet. Usually these black clothes are labels such as Lacoste and Polo. |
| True Blood | Synthetic blood made by the Japanese, which vampires can drink instead of human blood. This meets their nutritional requirements, rather then physical and emotional. |
| Undead | A being that is technically dead (no heartbeat), but is still animated as if it were alive. Whether it is the result of magic, a curse or maybe a virus, the human populace are led to believe it is the latter. |
| Unfortunate Incident | What the media calls it when a vampire "accidentally" kills a human, or when a vampire is killed. |
| Tribunal | A counil which decides and tries cases regarding vampires who have broken the law. |
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